Lymphoproliferative disorder in pleural effusion in a subject with past asbestos exposure. (2015)

• Record Type: Journal Article
• Authors: Hara, Naofumi; Fujimoto, Nobukazu; Miyamoto, Yosuke; Yamagishi, Tomoko; Asano, Michiko; Fuchimoto, Yasuko; Wada, Sae; Ozaki, Shinji; Kishimoto, Takumi
• Is Part Of: Respiratory medicine case reports. Volume 16(2015)
• Page Start: 169
• Page End: 171
• Publication Date: 2015
• Subjects: Asbestos -- Lymphoma -- Mesothelioma -- Pleural effusion -- Thoracoscopy; PEL primary effusion lymphoma -- HHV human herpesvirus -- CT computed tomography -- DLBCL diffuse large B-cell lymphoma; Respiratory organs -- Diseases -- Periodicals; Chest -- Diseases -- Periodicals; Respiratory Tract Diseases -- Periodicals; Respiratory System -- Periodicals; Chest -- Diseases; Respiratory organs -- Diseases; Electronic journals; Periodicals; 616.2
• DOI: 10.1016/j.rmcr.2015.11.002
• Languages: English
• ISSNs: 2213-0071

Abstract

Abstract: Primary effusion lymphoma (PEL) is a subtype of non-Hodgkin lymphoma that presents as serous effusions without detectable masses or organomegaly. Here we report a case of PEL-like lymphoma in a patient with past asbestos exposure. A 65-year-old man was referred to our hospital due to dyspnea upon exertion. He had been exposed to asbestos for three years in the construction industry. Chest X-ray and CT images demonstrated left pleural effusion. Cytological analysis of the pleural effusion revealed large atypical lymphocytes with distinct nuclear bodies and high nucleus-to-cytoplasm ratio. Immunohistochemical analyses showed that the cells were CD20 +, CD3 −, CD5 −, and CD10 − . These findings led to a diagnosis of diffuse large B-cell lymphoma. PEL or PEL-like lymphoma should be considered a potential cause of pleural effusion in subjects with past asbestos exposure.