Hydroxyshengmanol-type triterpenoids from the aerial parts of Cimicifuga simplex Wormsk. (June 2015)

• Record Type: Journal Article
• Authors: Bao, Ni-Man; Nian, Yin; Wang, Wei-Hua; Liu, Xiao-Ling; Ding, Zhong-Tao; Qiu, Ming-Hua
• Is Part Of: Phytochemistry letters. Volume 12(2015:Jun.)
• Page Start: 200
• Page End: 202
• Publication Date: 2015-06
• Subjects: Cimicifuga simplex Wormsk -- Hydroxyshengmanol -- Acetylcholinesterase; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2015.04.005
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: New hydroxyshengmanol-type triterpenoids with a carbonyl group at C-15 are rare in cimicifuga spp. The absolute configuration of hydroxyshengmanol was initially determined through X-ray diffraction. Compounds 7 and 8 showed inhibitory activity on AchE. Abstract: New hydroxyshengmanol-type triterpenoids (1–8) were identified from the aerial parts of cimicifuga simplex Wormsk by comprehensive 1D and 2D NMR, MS, and single-crystal X-ray diffraction analyses. The absolute configuration of the himeketal carbon (C-16) in hydroxyshengmanol-type constituents from cimicifuga spp. was initially determined as R using X-ray diffraction. All compounds were evaluated for their cytotoxicity in a panel of cancer cell lines and acetylcholinesterase inhibitory activity.