Diterpenoids from the stems of Tripterygium hypoglaucum (Celastraceae) and cytotoxic evaluation. (June 2015)

• Record Type: Journal Article
• Authors: Li, Xiao-Lei; Gao, Ling-Huan; Li, Hong-Mei; Wang, Li-Ting; Lee, Kuo-Hsiung; Li, Rong-Tao
• Is Part Of: Phytochemistry letters. Volume 12(2015:Jun.)
• Page Start: 84
• Page End: 89
• Publication Date: 2015-06
• Subjects: Tripterygium hypoglaucum -- Celastraceae -- Diterpenoid -- Cytotoxicity; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2015.02.018
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Four new diterpenoids (1 –4 ), along with seven known ones (5 –11 ), were isolated from Tripterygium hypoglaucum . Triptolide (5 ) and 2-epitripdiolide (6 ) showed significant anti-tumor activity. Highlights: Eleven diterpenoids were isolated including four new ones. The structures of the four new diterpenoids were determined. Anti-tumor, anti-inflammatory and anti-HIV activities of compounds were evaluated. Triptolide (5 ) and 2-epitripdiolide (6 ) showed significant cytotoxicity. Abstract: Four new diterpenoids, 2α, 16α-hydroxy- ent -kauran-19, 20-olide (1 ), isopimara-8(14), 15-diene-11β, 19-diol (2 ), isopimara-8(14), 15-diene-12α, 19-diol (3 ), and 3-oxo-14, 15-dihydroxyabieta-8, 11, 13-trien-19-ol (4 ), along with seven known compounds (5 –11 ) were isolated from Tripterygium hypoglaucum . Their structures were established on the basis of extensive spectroscopic analysis. Triptolide (5 ) and 2-epitripdiolide (6 ) showed significant cytotoxicity against A549, DU145, KB, KBvin and MDA-MB-231 cell lines with IC50 values of 0.0012–0.1306 μM in vitro .