Antiviral flavones from the leaves of Nicotiana tabacum. (June 2015)

• Record Type: Journal Article
• Authors: Yuan, Lin; Huang, Wenzhong; Zhang, Chengming; Xiang, Nengjun; Liu, Chunbo; Yang, Guangyu; Chen, Yongkuang; Miao, Mingming; Ma, Yinhai
• Is Part Of: Phytochemistry letters. Volume 12(2015:Jun.)
• Page Start: 75
• Page End: 78
• Publication Date: 2015-06
• Subjects: Nicotiana tabacum -- Flavones -- Tabaflavones A–C -- Anti-tobacco mosaic virus activity; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2015.02.003
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Three new flavones, tabaflavones A–C (1–3) were isolated from the leaves of Nicotiana tabacum, together with three known flavones. Highlights: Three new flavones, tabaflavones A–C, were isolated from Nicotiana tabacum . All compounds were evaluated for activity against the tobacco mosaic virus. Tabaflavone A exhibited moderate anti-TMV activity with an inhibition rate of 29.2%. Abstract: Three new flavones, tabaflavones A–C (1–3 ), together with three known flavones (4–6 ), were isolated from the leaves of Nicotiana tabacum . Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1–6 were evaluated for their anti-tobacco mosaic virus (anti-TMV) activities. The results showed compound 1 exhibited moderate anti-TMV activity with inhibition rate of 29.2%, which is close to that of the positive control. The other compounds also showed the anti-TMV activities with inhibition rates in the range of 14.2–20.8%.