Cytotoxic clerodane furanoditerpenoids from the root of Tinospora sagittata. (June 2015)

• Record Type: Journal Article
• Authors: Qin, Ning-bo; Wang, Ao-li; Li, Da-hong; Wang, Kai-bo; Lin, Bin; Li, Zhan-lin; Hua, Hui-ming
• Is Part Of: Phytochemistry letters. Volume 12(2015:Jun.)
• Page Start: 173
• Page End: 176
• Publication Date: 2015-06
• Subjects: Tinospora sagittata -- Clerodane-type furanoditerpenoid -- Cytotoxicity; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2015.03.014
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: We isolated two new clerodane-type furanoditerpenoids from the root of T. sagittata . We evaluated their antitumor activities against HL-60 and MCF-7 cell lines. We identified the absolute configuration of compound 1 by the calculated ECD for the first time. Abstract: Two new clerodane-type furanoditerpenoids, tinosporins A (1 ) and B (2 ), along with two known compounds columbin (3 ) and fibaruretin B (4 ), were isolated from the root of Tinospora sagittata (Oliv.) Gagnep. Their structures were elucidated by extensive spectroscopic analyses, including 1D NMR ( 1 H and 13 C NMR), 2D NMR (HMBC and NOESY) and HR-ESI-MS, and by the comparison of the spectroscopic data with literature values. The absolute configurations of compounds 1 and 2 were determined by CD analysis. Compound 1 showed moderate cytotoxicity against HL-60 and MCF-7 cell lines.