Phytochemical characterisation of a cytotoxic stem bark extract of Steganotaenia araliacea and identification of a protoflavanone by LC–SPE–NMR. (June 2015)

• Record Type: Journal Article
• Authors: I. Rica Capistrano, ; Wouters, An; Foubert, Kenn; Baldé, Aliou M.; Apers, Sandra; Lardon, Filip; Pieters, Luc; Exarchou, Vassiliki
• Is Part Of: Phytochemistry letters. Volume 12(2015:Jun.)
• Page Start: 119
• Page End: 124
• Publication Date: 2015-06
• Subjects: Steganotaenia araliacea -- Apiaceae -- Spiropreussomerin A -- Conrauiflavonol/afzelin A -- Protoflavonoid -- Steganoprotoflavanone; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2015.03.008
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: Cytotoxicity of Steganotaenia araliacea extract against several cancer cell lines. Identification of spiropreussomerin A and the flavanonol conrauiflavonol/afzelin A. Identification of a novel protoflavonoid steganoprotoflavanone. Abstract: A 80% ethanolic stem bark extract of Steganotaenia araliacea (Apiaceae) showed cytotoxic properties against MDA-MB-231 (breast), PANC-1 (pancreas) and HT-29 (colon) cancer cell lines. Phytochemical investigations by LC-SPE-NMR led to the identification of spiropreussomerin A, most probably produced by an endophytic fungus, the flavanonol conrauiflavonol / afzelin A, and a protoflavanone that has not been reported before and for which the name steganoprotoflavanone was adopted. Surprisingly none of the previously reported cytotoxic dibenzocyclo-octadiene lactone lignans was obtained as a major constituent of the cytotoxic extract.