Effects of methyl isocyanate on rat brain cells in culture. Issue 9 (September 1990)

• Record Type: Journal Article
• Authors: Anderson, D; Goyle, S; Phillips, B J; Tee, A; Beech, L; Butler, W H
• Is Part Of: Occupational and environmental medicine. Volume 47:Issue 9(1990)
• Page Start: 596
• Page End: 601
• Publication Date: 1990-09
• Subjects: Medicine, Industrial -- Periodicals; Environmental health -- Periodicals; 616.980305
• DOI: 10.1136/oem.47.9.596
• Languages: English
• ISSNs: 1351-0711

Abstract

Abstract : Since the disaster in Bhopal, India, people exposed to methyl isocyanate (MIC) have complained of various disorders including neuromuscular dysfunction. In an attempt to get information about such dysfunction we have previously shown that MIC can affect muscle cells in culture. The present communication reports investigations into the effect of MIC on brain cells in culture. MIC was toxic to brain cells and the response was dose related. The observations were supported by light and electron microscopy.