Laser interstitial thermal therapy in gliomas. (1st April 2020)

• Record Type: Journal Article
• Authors: Bozinov, Oliver; Yang, Yang; Oertel, Markus F.; Neidert, Marian C.; Nakaji, Peter
• Is Part Of: Cancer letters. Volume 474(2020)
• Page Start: 151
• Page End: 157
• Publication Date: 2020-04-01
• Subjects: Laser interstitial thermal therapy -- Blood brain barrier -- Immunotherapy -- Gliomas; Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2020.01.024
• Languages: English
• ISSNs: 0304-3835

Abstract

Abstract: Laser interstitial thermal therapy (LITT) has been used for brain metastasis, epilepsy, and necrosis, as well as gliomas as a minimally invasive treatment for many years. With the improvement of the thermal monitoring and ablation precision, especially the application of magnetic resonance (MR) thermography in the procedure and the available two commercial laser systems nowadays, LITT is gradually accepted by more neurosurgical centers. Recently, some new concepts, for example the adjuvant chemotherapy or radiation following LITT, the combination of immunotherapy and LITT regarding the glioma treatment are proposed and currently being investigated. The aim of this study is to summarize the evolution of LITT especially for brain gliomas and a possible outlook of the future. Highlights: Laser interstitial thermal therapy as a minimally invasive treatment for glioma. Breakdown of the blood brain barrier following LITT -- adjuvant chemotherapy or radiotherapy. Combination of LITT and immediate immunotherapy for butterfly gliomas.