Investigation of a He micro plasma-jet utilized for treatment of prostate cancer cells. (25th October 2019)

• Record Type: Journal Article
• Authors: Talviste, Rasmus; Raud, Sirli; Jõgi, Indrek; Plank, Toomas; Raud, Jüri; Teesalu, Tambet
• Is Part Of: Plasma research express. Volume 1:Number 4(2019)
• Publication Date: 2019-10-25
• Subjects: micro atmospheric pressure plasma jet (μ-APPJ) -- reactive oxygen and nitrogen species (RONS) -- plasma activated medium (PAM) -- plasma medicine; Plasma (Ionized gases) -- Periodicals; 530.44
• DOI: 10.1088/2516-1067/ab4ea9
• Languages: English
• ISSNs: 2516-1067

Abstract

Abstract: Present study investigated the applicability of the macro-kinetic description for RONS production by an atmospheric pressure micro-plasma jet operated in He gas flow. The concentrations of H2 O2, NO2 − and NO3 − in the deionized water were measured using UV absorption spectroscopy. The contact and non-contact modes were identified and the concentrations of H2 O2, NO2 − and NO3 − were higher in the contact mode. In the contact mode the concentrations of H2 O2 and NO3 − increased with the applied voltage and treatment duration while He flow rate also influenced the concentrations. The production rates of H2 O2 and NO3 − correlated with the amount of transferred charge of ionization waves during positive half period. The dependence of the production rates of RONS on the He flow rate suggests that the gas flow influences the gas composition in active discharge zone and limits the applicability of macro-kinetic model with the used plasma jet setup. As a potential application the plasma treated water was applied to prostate cancer cells. The viability of prostate cancer cell decreased linearly with the increase of H2 O2 and NO3 − concentrations while the NO2 − concentration had no clear correlation with cell viability. The H2 O2 was found to be the main agent responsible for the decreased cell viability. The amount of dissolved NO3 − on the other hand determined the pH of the plasma treated water.