Mechanism of pattern recognition receptors (PRRs) and host pathogen interplay in bovine mastitis. (July 2018)

• Record Type: Journal Article
• Authors: Bhattarai, Dinesh; Worku, Tesfaye; Dad, Rahim; Rehman, Zia Ur; Gong, Xiaoling; Zhang, Shujun
• Is Part Of: Microbial pathogenesis. Volume 120(2018)
• Page Start: 64
• Page End: 70
• Publication Date: 2018-07
• Subjects: Mastitis -- Signaling pathway -- Immune response -- Bacteria; Pathogenic microorganisms -- Periodicals; Pathology, Molecular -- Periodicals; Communicable Diseases -- microbiology -- Periodicals; Communicable Diseases -- parasitology -- Periodicals; Micro-organismes pathogènes -- Périodiques; Pathologie moléculaire -- Périodiques; Electronic journals; 616.9041
• DOI: 10.1016/j.micpath.2018.04.010
• Languages: English
• ISSNs: 0882-4010

Abstract

Abstract: Bacterial infection in the mammary gland parenchyma induces local and subsequently systemic inflammation that results in a complex disease. Mastitis in bovine is the result of various factors which function together. This review is aimed to analyze the factors involved in the pathogenesis of common bacterial species for bovine mastitis. The bacterial growth patterns, signaling pathway and the pathogen-associated molecular patterns (PAMPs) which activate immune responses is discussed. Clear differences in bacterial infection pattern are shown between bacterial species and illustrated TLRs, NLRs and RLGs molecular mechanism for the initiation of intramammary infection. The underlying reasons for the differences and the resulting host response are analyzed. Understandings of the mechanisms that activate and regulate these responses are central to the development of efficient anticipatory and treatment management. The knowledge of bovine mammary gland to common mastitis causing pathogens with possible immune mechanism could be a new conceptual understanding for the prospect of mastitis control program. Highlights: Bovine Mastitis as inflammatory response in udder tissue which is dependent on the quantity of PMNL that is further affected by the cellular process like apoptosis and necrosis. PRRs include TLRs, NLRs, and RLRs receptors which recognize various pathogen motifs by the process of Microbe-Associated Molecular Patterns (MAMPs) during mastitis. Immune-genetics is long term strategy for encountering development of therapeutics based for future.