Dimeric dehydroaporphinoids with antiplasmodial properties from the liana of Artabotrys aurantiacus (Annonaceae). (August 2020)

• Record Type: Journal Article
• Authors: Nguemdjo Chimeze, Valery Wilfried; Zühlke, Sebastian; Mbazoa Djama, Céline; Eckelmann, Dennis; Wandji, Jean
• Is Part Of: Phytochemistry letters. Volume 38(2020)
• Page Start: 150
• Page End: 154
• Publication Date: 2020-08
• Subjects: Annonaceae -- Artabotrys aurantiacus -- Dimeric dehydroaporphinoids -- Aurantiacine A-B -- HRESI-MSn and NMR spectroscopy -- Anti-plasmodial activities; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2020.06.009
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: 2 novel and 9 known compounds were isolated from Artabotrys aurantiacus . Their structures were determined by 1D and 2D NMR spectra and MS data. Compounds 1 -4 exhibited moderate activities against Plasmodium Falciparum NF54. Abstract: Artabotrys aurantiacus is a Cameroonian Medicinal plant used in traditional medicines to fight against Malaria. So far, there is no reported data on the chemical composition of this plant. From the CH2 Cl2 /MeOH (1:1) extract of the liana of A. aurantiacus, two new dimeric dehydroaporphine alkaloids, aurantiacine A (1 ) and B (2 ) were isolated along with nine known compounds. Their chemical structures were elucidated by means of HRESI-MS n and spectroscopic methods, including 1D and 2D NMR, and by comparison with data from the literature. The isolated compounds were evaluated for their anti-plasmodial activity in vitro against the erythrocytic stage of Plasmodium falciparum NF54. Compounds 1 -4 displayed moderate anti-plasmodial properties with IC50 values of 0.6336, 0.1120, 0.2601 and 1.0159 μM respectively.