Estimation of the local production of antibodies to Treponema pallidum in the central nervous system of patients with neurosyphilis. Issue 2 (April 1983)

• Record Type: Journal Article
• Authors: Müller, F; Moskophidis, M
• Is Part Of: Sexually transmitted infections. Volume 59:Issue 2(1983)
• Page Start: 80
• Page End: 84
• Publication Date: 1983-04
• Subjects: Sexually transmitted diseases -- Periodicals; HIV infections -- Periodicals; 616.951005
• DOI: 10.1136/sti.59.2.80
• Languages: English
• ISSNs: 1368-4973

Abstract

Abstract : In 76% of 149 patients with neurosyphilis local production of treponema-specific IgG antibodies in the central nervous system (CNS) was determined by estimating the cerebrospinal fluid (CSF)-to-serum ratio of TPHA-IgG titre per mg total IgG. With this formula synthesis of treponema-specific IgG antibodies in the CNS could be detected independently of the function of the blood-CSF barrier. A selective increase of total IgG in the CSF was not found in all cases. Forty-three patients with adequately treated or spontaneously resolved syphilis without clinical evidence of involvement of the CNS by Treponema pallidum served as controls.