Caveolin‐1 as a possible target in the treatment for acne. Issue 2 (9th December 2019)

• Record Type: Journal Article
• Authors: Kruglikov, Ilja L.; Scherer, Philipp E.
• Is Part Of: Experimental dermatology. Volume 29:Issue 2(2020)
• Page Start: 177
• Page End: 183
• Publication Date: 2019-12-09
• Subjects: acne -- autophagy -- C. acnes -- caveolin -- follicular hyperkeratinization -- hyperseborrhea -- innate immunity -- pathophysiology; Dermatology -- Periodicals; 616.5
• DOI: 10.1111/exd.14063
• Languages: English
• ISSNs: 0906-6705

Abstract

Abstract: Expression of caveolin‐1 (Cav‐1) is an important pathophysiological factor in acne. Cav‐1 strongly interacts with such well‐recognized etiopathogenic factors such as hyperseborrhea, follicular hyperkeratinization and pathogenicity of Cutibacterium acnes . Cav‐1 is a strong negative regulator of transforming growth factor beta (TGF‐β) expression. It acts as a critical determinant of autophagy, which is significantly induced in acne lesions through C. acnes and by absorption of fatty acids. Cav‐1 also demonstrates different correlations with the development of innate immunity. We propose that normalization of Cav‐1 expression can serve as a target in anti‐acne therapy.