Relationship Between Fat‐Soluble Vitamin Supplementation and Blood Concentrations in Adolescent and Adult Patients With Cystic Fibrosis. (17th April 2014)

• Record Type: Journal Article
• Authors: Siwamogsatham, Oranan; Dong, Wei; Binongo, Jose N.; Chowdhury, Ritam; Alvarez, Jessica A.; Feinman, Shawna J.; Enders, Jessica; Tangpricha, Vin
• Is Part Of: Nutrition in clinical practice. Volume 29:Number 4(2014:Aug.)
• Page Start: 491
• Page End: 497
• Publication Date: 2014-04-17
• Subjects: cystic fibrosis -- vitamin D -- vitamin A -- vitamin E -- vitamin K -- avitaminosis; Nutrition -- Periodicals; Diet therapy -- Periodicals; Artificial feeding -- Periodicals; 615.854
• DOI: 10.1177/0884533614530170
• Languages: English
• ISSNs: 0884-5336

Abstract

Abstract : Background : Pancreatic insufficiency is common in patients with cystic fibrosis (CF) and leads to malabsorption of fat‐soluble vitamins. Multivitamins, including vitamins A, D, E, and K, are routinely prescribed to patients with CF to prevent vitamin deficiencies. Our objective was to examine the relationship between fat‐soluble vitamin supplements and their impact on blood concentrations. Methods : This was a retrospective chart review of patients with CF who were treated at Emory Clinic and Emory University Hospital during 2008–2012. The amount of fat‐soluble vitamin supplementation, serum markers of fat‐soluble vitamin concentrations, CF transmembrane conductance regulator genotype, and other demographic information were recorded from electronic medical records. Mixed‐effects models were used to investigate the trends over time of fat‐soluble vitamin supplements and serum vitamin concentrations. Results : In total, 177 charts were eligible. Mean (SD) age was 26.1 (10.2) years. Ninety‐two percent of patients had pancreatic insufficiency and 52% had the homozygous ΔF508 mutation. Recorded fat‐soluble vitamin supplementation increased in the past 5 years ( P < .001 for all). Serum 25‐hydroxyvitamin D increased slightly (3% increase; P < .01); however, there were no changes in the blood concentrations of vitamins A, E, and K ( P = .26–.96). Conclusions : Despite a near doubling of recorded fat‐soluble vitamin supplementation over the past 5 years, there was no parallel increase in blood concentrations of these vitamins. Potential reasons include suboptimal dosages, low adherence, or ongoing issues with malabsorption.