Biomineralization: Physicochemical and Biological Properties of Biomimetic Mineralo‐Protein Nanoparticles Formed Spontaneously in Biological Fluids (Small 13/2013). Issue 13 (1st July 2013)

• Record Type: Journal Article
• Authors: Peng, Hsin‐Hsin; Wu, Cheng‐Yeu; Young, David; Martel, Jan; Young, Andrew; Ojcius, David M.; Lee, Yu‐Hsiu; Young, John D.
• Is Part Of: Small. Volume 9:Issue 13(2013:Jul.)
• Page Start: 2372
• Page End: 2372
• Publication Date: 2013-07-01
• Subjects: biological fluids -- biomimetics -- biomineralization -- mineralo‐protein complexes -- nanobacteria; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.201370074
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract : The properties of biological mineralo‐protein nanoparticles that form spontaneously in human body fluids are described by J. D. Young and co‐workers on page 2297 . Concentrations of serum and precipitating ions near physiological levels produce small biomimetic nanoparticles that grow steadily in size but retain a similar protein profile irrespective of size. These biological mineral particles are phagocytosed by immune cells and they activate pro‐inflammatory responses in a size‐dependent manner.