Cover Picture: The TEAD4–YAP/TAZ Protein–Protein Interaction: Expected Similarities and Unexpected Differences (ChemBioChem 10/2013). Issue 10 (1st July 2013)

• Record Type: Journal Article
• Authors: Hau, Jean Christophe; Erdmann, Dirk; Mesrouze, Yannick; Furet, Pascal; Fontana, Patrizia; Zimmermann, Catherine; Schmelzle, Tobias; Hofmann, Francesco; Chène, Patrick
• Is Part Of: Chembiochem. Volume 14:Issue 10(2013)
• Page Start: 1149
• Page End: 1149
• Publication Date: 2013-07-01
• Subjects: Hippo pathway -- omega loops -- peptides -- protein–protein interactions -- TAZ -- TEAD -- YAP; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1002/cbic.201390033
• Languages: English
• ISSNs: 1439-4227

Abstract

Abstract : The cover picture shows a schematic view of the interaction between the YAP and TAZ co‐activators with a TEAD transcription factor. TEAD transcription factors are key elements of the Hippo pathway, which is deregulated in various types of cancers. YAP and TAZ share a high sequence homology and bind with similar affinity at the same site on the TEAD surface. However, this apparent similarity conceals differences in the ways in which both co‐activators interact with TEAD. On p. 1218 ff., P. Chène et al. depict the similarities and differences of the TEAD4–YAP/TAZ protein–protein interaction.