Cost-effectiveness of introducing a domestic pneumococcal conjugate vaccine (PCV7-TT) into the Cuban national immunization programme. (August 2020)

• Record Type: Journal Article
• Authors: García Fariñas, Anai; Linares-Pérez, Nivaldo; Clark, Andrew; Toledo-Romaní, María Eugenia; Omeiri, Nathalie El; Marrero Araújo, Martha C.; Gonzálvez Luis, Isabel Pilar; Toraño Peraza, Gilda; Reyes Jiménez, Alicia; López Ambrón, Lena; Rodríguez, Meiby C.; Paredes, Beatriz; Mirabal, Mayelín; Cuevas, Ivan; García-Rivera, Dagmar; Rodríguez, Laura M.; Martínez, Marisel; Valdés-Balbín, Yuri; Toraño Peraza, Gilda; Borroto Gutiérrez, Susana; Rodríguez Ortega, Misladys; María Gálvez, Ana; Casanova, Maria F.; Chavez, Dunia; Reyes, Alaín; de Oca, Yaima Figueredo Montes; Fonseca, Mercedes; de Oca, Martha Montes; Velázquez Águila, Antonio; García Rodríguez, Iliana; Llul Tombo, Cary Tere; Yanes Macías, Juan C.; Elena Mesa, Maria; Ricardo, Yariser; Molina Águila, Niurka; Legarreta Peňa, Ernesto; Vega Mendoza, Dania; Gladys Fuentes, Gladys Abreu; Pérez Orta, Miosotis; Infante, Concepción; Reyes López, María Cristina; Teresita Ramos, Lidia; Áreas, Itciar; Rodríguez, Adriana; Herrera López, Josefina; Donatién Rojas, Nordis Caridad; Batista Caluff, Lissett; Cobas Limonta, Nivia; Moraima, ; Justiz Hernández, Silvia; García, Malfran; Rondón Rondón, Luis Enrique; Rondón Peña, Bertha Isabel; Pajaro Medina, Magdevis; Díaz Teran, Daisy; Cuza Ferrer, Mariela; Maren González, María; Maceira Soto, Samira; Guillén, José R.; Rodriguez Fonseca, Amanda; Mederos Reyes, Carlos; Reyes Sebasco, Alain; Janusz, Cara; Pérez, Alina;
• Is Part Of: International journal of infectious diseases. Volume 97(2020)
• Page Start: 182
• Page End: 189
• Publication Date: 2020-08
• Subjects: Pneumococcal conjugate vaccine -- Cost effectiveness -- Cuba; Communicable diseases -- Periodicals; Communicable Diseases -- Periodicals; Communicable diseases; Periodicals; Electronic journals; 616.9
• DOI: 10.1016/j.ijid.2020.05.078
• Languages: English
• ISSNs: 1201-9712

Abstract

Highlights: Introducing a domestic pneumococcal conjugate vaccine is likely to be cost-effective in Cuba. In a 'worst case' scenario, cost per DALY averted was still less than 0.4 GDP per capita. The impact of the vaccine would need to be monitored following its introduction. Abstract: Objectives: To evaluate the cost-effectiveness of introducing a domestic pneumococcal conjugate vaccine (PCV7-TT) into the Cuban National Immunization Program (NIP). Methods: We compared PCV7-TT given at two, four and six months of age to a scenario without PCV7-TT, over a ten-year period (2020–2029). We calculated the cost (Cuban pesos – CUP) per Disability Adjusted Life Year (DALY) averted from a Government perspective. We compared results from a static cohort model and a parsimonious prediction model informed by the serotype distribution among pneumococcal carriers and cases. We ran probabilistic and deterministic uncertainty analyses. Results: PCV7-TT could prevent 6897 (95% uncertainty interval, 4344–8750) hospitalizations and 189 (115–253) deaths in children <5 years of age, over the period 2020–2029. This could cost around 25 million (20–31) discounted CUP but would be offset by treatment cost savings of around 23 million (14–31). A parsimonious model predicted less favourable impact and cost-effectiveness but the cost per DALY averted was still less than 0.4 times the current GDP per capita. Conclusions: PCV7-TT is likely to be cost-effective in Cuba. The impact of the vaccine would need to be carefully monitored following its introduction into the NIP.