Murine pulmonary imaging at 7T: T2* and T1 with anisotropic UTE. Issue 4 (15th August 2017)

• Record Type: Journal Article
• Authors: Guo, Jinbang; Cao, Xuefeng; Cleveland, Zackary I.; Woods, Jason C.
• Is Part Of: Magnetic resonance in medicine. Volume 79:Issue 4(2018)
• Page Start: 2254
• Page End: 2264
• Publication Date: 2017-08-15
• Subjects: UTE MRI -- T2*; T1; ellipsoidal k‐space coverage; murine lung; Nuclear magnetic resonance -- Periodicals; Electron paramagnetic resonance -- Periodicals; 616.07548
• DOI: 10.1002/mrm.26872
• Languages: English
• ISSNs: 0740-3194

Abstract

Abstract : Purpose: To measure the T 2 * and T1 of mouse lung at 7T via anisotropic‐resolution radial ultrashort echo‐time imaging with ellipsoidal k‐space coverage. Methods: Ellipsoidal field‐of‐view was created by expanding uniform spherical k‐space coverage. The effects of T 2 * and ellipsoidal sampling on image resolution were investigated by using point‐spread‐function analysis and resolution phantoms. Finally, this ellipsoidal sampling approach was used to measure the lung T 2 * and T1 of healthy C57BL/6 mice at the increasingly common preclinical field strength of 7T. Results: Lung parenchyma T 2 * of 17‐ to 23‐week‐old mice at 7T was 0.395 ± 0.033 ms. T1 of lung and left‐ and right‐heart ventricles was 1452.5 ± 87.0 ms, 1810.5 ± 54.6 ms, and 1602.6 ± 120.9 ms, respectively. Ellipsoidal k‐space sampling provides enhanced resolution for a fixed scanning time or provides equivalent (although anisotropic) spatial resolution with reduced scanning times, while simultaneously avoiding fold‐in artifacts. Conclusion: Using these techniques, the first T 2 * and T1 measures of mouse lung at 7T are reported. Ultrashort echo‐time imaging with ellipsoidal k‐space coverage significantly increases in‐plane resolution without increasing scanning time, or equivalently, decreases scanning time while maintaining equivalent in‐plane resolution. Magn Reson Med 79:2254–2264, 2018. © 2017 International Society for Magnetic Resonance in Medicine.