The potential biomedical platforms based on the functionalized Gd@C82 nanomaterials. Issue 1 (23rd March 2020)

• Record Type: Journal Article
• Authors: Li, Xue; Wang, Chunru
• Is Part Of: View. Volume 1:Issue 1(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-03-23
• Subjects: Antineoplastic activities -- Functionalized Gd@C82 nanomaterials -- Metabolic disease regulators -- MRI contrast agents -- Vascular disrupting agents; Drug delivery systems -- Periodicals; Bioengineering -- Periodicals; Bioinformatics -- Periodicals; Biomedical materials -- Periodicals; 681.761
• DOI: 10.1002/viw2.7
• Languages: English
• ISSNs: 2688-3988

Abstract

Abstract: Gadolinium metallofullerene (Gd@C82 ), a novel star carbonaceous material, has allured considerable attention due to its attractive properties. Increasing evidence exhibits that functionalized Gd@C82 nanomaterials have great potential in various biomedical applications. Except for the earliest bioapplication as the next‐generation of magnetic resonance imaging contrast agent, Gd@C82 nanomaterials perform excellent anti‐cancer activities. Functionalized Gd@C82 nanomaterials could inhibit tumor growth by suppressing tumor angiogenesis, cutting off the existing tumor vasculature under radiofrequency irradiation or modulating immune cells. In addition, Gd@C82 nanomaterials could be adjuvant agents to lower the toxicity of chemotherapeutic drugs and alleviate drug resistance. In particular, Gd@C82 nanomaterials are demonstrated to regulate glucose and lipid metabolism, presenting superior anti‐type 2 diabetes mellitus effects. With no detectable toxicity and pleiotropic biological effects, Gd@C82 nanomaterials could be promising biomedical platforms in the future. Abstract : Functionalized Gd@C82 nanomaterials have been used in various biomedical fields, such as cancer diagnosis and treatment, glucose and lipid modulation, etc. With no detectable toxicity and pleiotropic biological effects, Gd@C82 nanomaterials could be promising biomedical platforms in clinical usein the future.