Chemotherapy improves thymoma-associated graft-versus-host-disease-like erythroderma. (10th May 2011)

• Record Type: Journal Article
• Authors: Nagano, Tatsuya; Kotani, Yoshikazu; Kobayashi, Kazuyuki; Tomita, Nanako; Nakata, Kyosuke; Sakashita, Akihiro; Funada, Yasuhiro; Nagai, Hiroshi; Itoh, Tomoo; Nishimura, Yoshihiro
• Is Part Of: BMJ case reports. Volume 2011
• Publication Date: 2011-05-10
• Subjects: Medicine -- Case studies -- Periodicals; 610.5
• DOI: 10.1136/bcr.03.2011.3936
• Languages: English
• ISSNs: 1757-790X

Abstract

Abstract : Graft-versus-host-disease (GVHD) with erythroderma can rarely occur in the context of thymoma and is associated with a poor prognosis due to an increased risk of infection-related death. The present study describes a case of a 50-year-old man with malignant thymoma who developed sepsis in addition to skin manifestations similar to that seen in GVHD. This patient experienced marked improvement in skin lesions in response to steroids and combination chemotherapy with carboplatin and paclitaxel, with subsequent resolution of infection. The present study describes the clinical course of this patient, followed by a review of pertinent reports of thymoma associated with GVHD with particular focus on the efficacy of treatment strategies.