Aminopyridine derived azomethines as potent antimicrobial agents. (2021)

• Record Type: Journal Article
• Authors: Mashood Ahamed, F.M.; Ali, Arshad M.; Velusamy, V.; Manikandan, M.
• Is Part Of: Materials today. Volume 47:Part 9(2021)
• Page Start: 2053
• Page End: 2061
• Publication Date: 2021
• Subjects: Amino pyridine -- Antimicrobial activity -- Schiff bases -- Antioxidant -- FTIR; Materials science -- Congresses -- Periodicals; 620.1
• DOI: 10.1016/j.matpr.2021.04.424
• Languages: English
• ISSNs: 2214-7853

Abstract

Abstract: Imines are synthetically accessible and structurally diverse compounds, typically obtained by facile condensation between an aldehyde, or a ketone with primary amines, sometimes known as Schiff bases. Imines contain an azomethine (-C = N) linkage that stitches together two or more biologically active aromatic/heterocyclic scaffolds to form various molecular hybrids with interesting biological properties. Schiff bases are versatile compounds with vast therapeutic applications such as antibacterial including antimycobacterial, antifungal, antiviral, antimalarial, anti-inflammatory, antioxidant, pesticidal, cytotoxic, enzyme inhibitory, and anticancer including DNA damage. Based on the above consideration an attempt has been made to synthesize Schiff bases by reacting diketones/ketoesters with substituted 2-aminopyridines. Structures of the compounds were well established by FT-IR, 1 H & 13 C NMR and mass spectral studies. Further the compounds were screened for in-vitro antimicrobial activity employing agar dilution method. All the compounds showed excellent antimicrobial activity against the bacterial and fungi pathogens.