Diabetes Distal Peripheral Neuropathy: Subtypes and Diagnostic and Screening Technologies. (March 2022)

• Record Type: Journal Article
• Authors: Newlin Lew, Kelley; Arnold, Tracey; Cantelmo, Catherine; Jacque, Francky; Posada-Quintero, Hugo; Luthra, Pooja; Chon, Ki H.
• Is Part Of: Journal of diabetes science and technology. Volume 16:Number 2(2022)
• Page Start: 295
• Page End: 320
• Publication Date: 2022-03
• Subjects: diabetes -- diagnostic technologies -- distal symmetrical peripheral neuropathy -- large-fiber neuropathy -- small-fiber neuropathy; Diabetes -- Periodicals; Medical technology -- Periodicals; Diabetes Mellitus -- Periodicals; 616.462005
• DOI: 10.1177/19322968211035375
• Languages: English
• ISSNs: 1932-2968

Abstract

Diabetes distal symmetrical peripheral neuropathy (DSPN) is the most prevalent form of neuropathy in industrialized countries, substantially increasing risk for morbidity and pre-mature mortality. DSPN may manifest with small-fiber disease, large-fiber disease, or a combination of both. This review summarizes: (1) DSPN subtypes (small- and large-fiber disease) with attention to clinical signs and patient symptoms; and (2) technological diagnosis and screening for large- and small-fiber disease with inclusion of a comprehensive literature review of published studies from 2015-present ( N = 66). Review findings, informed by the most up-to-date research, advance critical understanding of DSPN large- and small-fiber screening technologies, including those designed for point-of-care use in primary care and endocrinology practices.