Complement activation and anaphylactoid response to protamine in a child after cardiopulmonary bypass. Issue 5 (May 1985)

• Record Type: Journal Article
• Authors: Westaby, S; Turner, M W; Stark, J
• Is Part Of: Heart. Volume 53:Issue 5(1985)
• Page Start: 574
• Page End: 576
• Publication Date: 1985-05
• Subjects: Heart -- Diseases -- Treatment -- Periodicals; Cardiology -- Periodicals; 616.12
• DOI: 10.1136/hrt.53.5.574
• Languages: English
• ISSNs: 1355-6037

Abstract

Abstract : A 2 1/2 year old boy had a sudden, severe, and unexpected anaphylactoid reaction after an otherwise uncomplicated repair of a partial atrioventricular septal defect. The reaction, comprising haemorrhagic pulmonary oedema and peripheral circulatory collapse, followed neutralisation of heparin by protamine. Measurements of serum complement (C3 and C4) concentrations suggested that a pronounced consumption of complement occurred during the adverse response.