Effect of spectinomycin on T. pallidum in incubating experimental syphilis. Issue 5 (October 1975)

• Record Type: Journal Article
• Authors: Petzoldt, D
• Is Part Of: Sexually transmitted infections. Volume 51:Issue 5(1975)
• Page Start: 305
• Page End: 306
• Publication Date: 1975-10
• Subjects: Sexually transmitted diseases -- Periodicals; HIV infections -- Periodicals; 616.951005
• DOI: 10.1136/sti.51.5.305
• Languages: English
• ISSNs: 1368-4973

Abstract

Abstract : Animal experiments were performed to determine if a single-dose treatment for acute gonorrhoea with 2 g. spectinomycin could cure a simultaneously acquired syphilis at a very early stage of incubation. 300 treponemes (Nichols stain T. pallidum) were inoculated intratesticularly and 3 days later spectinomycin was administered in a dose which produced spectinomycin serum levels similar to those in patients who had received a single oral dose of 2 g. This dosage of spectinomycin did not prevent the development of syphilitic orchitis or reactivity to the FTA-ABS test, but it prolonged the subclinical incubation period.