Clinical experience in the use of cefuroxime in gonorrhoea. Issue 6 (December 1978)

• Record Type: Journal Article
• Authors: Fowler, W; Rahim, G; Brown, J D
• Is Part Of: Sexually transmitted infections. Volume 54:Issue 6(1978)
• Page Start: 400
• Page End: 402
• Publication Date: 1978-12
• Subjects: Sexually transmitted diseases -- Periodicals; HIV infections -- Periodicals; 616.951005
• DOI: 10.1136/sti.54.6.400
• Languages: English
• ISSNs: 1368-4973

Abstract

Abstract : Cefuroxime, a new antibiotic derived from cephalosporin-C which is very stable in the presence of beta-lactamases produced by Gram-negative organisms, was used to treat 856 male patients and 340 female patients with uncomplicated gonorrhoea. In men the drug was used in three different doses, 1.5 g, 1 g, and 750 mg plus 1 g probenecid; in women 1 g and 750 mg cefuroxime plus 1 g probenecid was used. Cure rates ranged from 94.8% to 99.3%. The antibiotic was well tolerated and was free from side effects. Cefuroxime would be a valuable and efficient substitute for penicillin in the treatment of gonorrhoea due to beta-lactamase-producing strains of gonococci.