Minocycline hydrochloride (Minocin) as a single-dose oral treatment of uncomplicated gonorrhoea in men. Issue 1 (February 1976)

• Record Type: Journal Article
• Authors: Masterton, G; Schofield, C B
• Is Part Of: Sexually transmitted infections. Volume 52:Issue 1(1976)
• Page Start: 43
• Page End: 45
• Publication Date: 1976-02
• Subjects: Sexually transmitted diseases -- Periodicals; HIV infections -- Periodicals; 616.951005
• DOI: 10.1136/sti.52.1.43
• Languages: English
• ISSNs: 1368-4973

Abstract

Abstract : 349 male patients with uncomplicated gonococcal urethritis were treated with a single dose of 300 mg. or 400 mg. minocycline hydrochloride. The lower dose gave a lower failure rate, 3-2 compared with 5-1 per cent., but this difference was not statistically significant. The overall known failure rate of 4-2 per cent. compares most favourably with our previous findings in this area using other drugs of the tetracycline group. The incidence of post-gonococcal urethritis (5-1 per cent.) was also the lowest we have found. The few side-effects reported were comparatively trivial. Because of its high degree of therapeutic efficacy, the relatively lack of side-effects, and the reduced incidence of post-gonococcal urethritis, minocycline hydrochloride should be considered the drug of choice whenever single-dose oral treatment is given in uncomplicated gonorrhoea in men.