Serum levels of acute phase and cardiac proteins after myocardial infarction, surgery, and infection. Issue 4 (October 1982)

• Record Type: Journal Article
• Authors: Voulgari, F; Cummins, P; Gardecki, T I; Beeching, N J; Stone, P C; Stuart, J
• Is Part Of: Heart. Volume 48:Issue 4(1982)
• Page Start: 352
• Page End: 356
• Publication Date: 1982-10
• Subjects: Heart -- Diseases -- Treatment -- Periodicals; Cardiology -- Periodicals; 616.12
• DOI: 10.1136/hrt.48.4.352
• Languages: English
• ISSNs: 1355-6037

Abstract

Abstract : C-reactive protein and four other acute phase reactant proteins of non-cardiac, origin (orosomucoid, alpha 1- antitrypsin, heptoglobin, and alpha 2- macroglobulin) were studied serially by laser immunonephelometric assay in sera from 17 patients with myocardial infarction. A similar comparison was made in 57 patients undergoing surgery and 72 patients with acute infection. C-reactive protein was consistently the most sensitive acute phase reactant in all three conditions. After myocardial infarction, a raised serum C-reactive protein level was found on admission in four patients before a rise in creatine kinase MB isoenzyme (CK MB). The peak C-reactive protein level was reached on the third post-infarct day and it then declined over seven days with a half-life similar to myocardial tropomyosin. Serial monitoring of serum C-reactive protein, in parallel with cardiac proteins of short half-life (CK MB) and long half-life (tropomyosin), provides maximal information for diagnosis and for detecting post-infarct complications.