Superficial peroneal neuromodulation of nonobstructive urinary retention in cats. Issue 6 (16th June 2020)

• Record Type: Journal Article
• Authors: Zhao, Jun; Chen, Jialiang; Guo, Wenbin; Shapiro, Katherine; Mohapatra, Anand; Zhong, Yihua; Armann, Kody; Shen, Bing; Wang, Jicheng; Beckel, Jonathan; de Groat, William C.; Tai, Changfeng
• Is Part Of: Neurourology and urodynamics. Volume 39:Issue 6(2020:Aug.)
• Page Start: 1679
• Page End: 1686
• Publication Date: 2020-06-16
• Subjects: bladder -- peroneal -- stimulation -- tibial -- urinary retention; Urinary organs -- Periodicals; Urodynamics -- Periodicals; Urology -- Periodicals; 616.6
• DOI: 10.1002/nau.24438
• Languages: English
• ISSNs: 0733-2467

Abstract

Abstract: Aims: To determine if superficial peroneal nerve stimulation (SPNS) can improve nonobstructive urinary retention (NOUR). Methods: In α‐chloralose anesthetized cats, NOUR was induced by repetitive application (4‐16 times) of 30‐minute tibial nerve stimulation (TNS: 5 Hz frequency, 0.2 ms pulse width) at 4 to 6 times threshold intensity (T) for inducing toe twitches. SPNS (1 Hz, 0.2 ms) at 2 to 4 times threshold intensity (T) for inducing posterior thigh muscle contractions was applied either continuously (SPNSc) during a cystometrogram (CMG) or during voiding (SPNSv) by a surgically implanted cuff electrode or by skin surface electrodes to determine if the stimulation reduced NOUR induced by prolonged TNS. Results: During control CMGs, efficient (86.4% ± 5.5%) voiding occurred with a postvoid residual (PVR) volume equal to 14.9% ± 6.2% of control bladder capacity. NOUR elicited by prolonged TNS significantly ( P < .05) increased bladder capacity to 168.6% ± 15.5% of control, reduced voiding efficiency to 30.4% ± 4.8%, and increased PVR to 109% ± 9.2% of control. Using the implanted cuff electrode, SPNSc and SPNSv significantly ( P < .05) increased voiding efficiency to 66.7% ± 7.4% and 65.0% ± 5.9%, respectively, and reduced PVR to 52.2% ± 11.4% and 64.3% ± 11.6%, respectively. SPNSc but not SPNSv significantly ( P < .05) reduced bladder capacity to 133.4% ± 15% of control. Transcutaneous SPNSv but not SPNSc also significantly ( P < .05) reversed the TNS‐induced NOUR responses. Conclusions: This study shows that SPNS is effective in reversing NOUR induced by prolonged TNS. Transcutaneous SPNS provides the opportunity to develop a noninvasive neuromodulation therapy for NOUR to treat more patients than current sacral neuromodulation therapy.