Injectable Hydrogels in Repairing Central Nervous System Injuries. (20th September 2021)

• Record Type: Journal Article
• Authors: Sun, Huiyan; Zhang, Limin; Cheng, Wei; Hao, Fengxia; Zhou, Liyan; Li, Qiang
• Other Names: Gloria Antonio Academic Editor.
• Is Part Of: Advances in materials science and engineering. Volume 2021(2021)
• Publication Date: 2021-09-20
• Subjects: Materials science -- Periodicals; Materials science; Periodicals; 620.11
• DOI: 10.1155/2021/7381980
• Languages: English
• ISSNs: 1687-8434

Abstract

Abstract : The injured central nervous system (CNS) can hardly regenerate. In vitro engineering of brain tissue hits technical bottlenecks. Also, the compaction and complexity of anatomical structure defy the accurate positioning for lesion sites in intracranial injuries. Therefore, repairing injured CNS remains a significant clinical challenge. Various recent in vivo and in vitro experiments have demonstrated the excellent effect of tissue engineering on repairing central nerve cells and tissues through implanting new materials and engineered cells. Except for porous three-dimensional structures able to pad lesions in various shapes and simulate the natural extracellular matrix with nutrients for cell proliferation, hydrogels incorporate high biocompatibility. Injectable hydrogels with the merits of avoiding complex surgery on large wounds, filling irregular gaps, delivering drugs, and others, are of growing interest. This review focuses on the experimental studies regarding injectable hydrogels, especially applying various injectable hydrogels to repair brain damage.