Cellulose Fibrils Extracted from Bamboo Chips as a Reinforcing Material for Prolonged Drug Release. Issue 32 (24th August 2020)

• Record Type: Journal Article
• Authors: Yan, Guihua; Feng, Yunchao; Wang, Huiqiang; Sun, Yong; Tang, Xing; Zeng, Xianhai; Lin, Lu
• Is Part Of: ChemistrySelect. Volume 5:Issue 32(2020)
• Page Start: 9957
• Page End: 9965
• Publication Date: 2020-08-24
• Subjects: aerogel -- biocompatibility -- cellulose -- drug carrier -- stimuli-responsive; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.202001970
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: Despite significant improvements in the intelligent delivery of drugs, the search for drug carriers with low cost and long‐term sustainable release still faces enormous challenges. In this study this issue was addressed for porous cellulose‐based aerogels by developing a Temperature/pH stimuli‐responsive carrier for drug controlled release. The prepared aerogels exhibited a smart 3D network with large specific surface area (112.6 m 2 g −1 ) that facilitated the loading and transport of drug molecules. The aerogels were highly responsive to both temperature and pH in aqueous solution, which acted as a good switch for the molecular to control the release by adjusting the solution parameters. Moreover, the cell cytotoxicity and acute oral toxicity tests did not cause specific reactions and showed excellent biocompatibility. The simple manufacturing process, reversible drug release performance as well as the excellent biocompatibility make it a promising candidate for drug delivery. Abstract : The work reported a novel green assembling way of bamboo cellulose‐based temperature/pH stimuli‐responsive (on/off) aerogel. Attributed to the highly activity, biocompatibility, temperature/pH‐responsive, the aerogel exhibited excellent loading capacity and long‐term continuing release for soluble molecule. These properties make the aerogel an ideal candidate in drug delivery, medical carrier, cosmetics or food industry, which holds very promise for future evolvement.