LINKS BETWEEN VITAMIN D, C REACTIVE PROTEIN, LDL, OXIDIZED LDL AND ECG VARIABLES IN HYPERTENSIVE PATIENTS. (April 2021)

• Record Type: Journal Article
• Authors: Mozos, Ioana; Jianu, Daniela
• Is Part Of: Journal of hypertension. Volume 39(2021)e-Supplement 1
• Publication Date: 2021-04
• Subjects: Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/01.hjh.0000745512.11367.15
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Objective: The present paper aimed to assess the relationship of electrocardiographic variables with vitamin D, C reactive protein (CRP), LDL and oxidized LDL level, respectively, in hypertensive patients. Design and method: A total of 40 hypertensive patients underwent standard 12-lead ECG, which enabled measurement of P wave, PR and QT interval and QRS duration, as well as R wave in V5 and V6 and S wave in V1, V2. The following laboratory tests were performed: vitamin D (25-hydroxycholecalciferol: liquid chromatography method), CRP (immunophelometry), LDL (photometric method) and oxidized LDL (ELISA method). Results: QRS complex and heart rate corrected QT interval (QTc) duration were prolonged in 27.5% and 25%, respectively, of the patients. Vitamin D was less than 20 microg/l (D20) in 35% of the patients, and less than 30 microg/l (D30) in 77.5%. Significant correlations were found between vitamin D level and QRS duration (rS = −0.334, p = 0.035), QT (rS = 0.383, p = 0.015), QTc (rS = 0.366, p = 0.020), RV5 (rP = 0.682, p less than 0.001), RV6 (rP = 0.573, p less than 0.001), SV2 (rP = 0.356, p = 0.024). QRS duration correlated with CRP exceeding 0.300 mg/dl (rK = 0.423, p = 0.008). LDL level was significantly associated with a prolonged P wave duration (P120) (rP = −0.327, p = 0.039). No correlation was found between oxidized LDL level and ECG variables. Conclusions: Vitamin D level can provide valuable information about QRS duration, QT interval, R in V5 and V6 and S in V2, CRP about QRS duration, and LDL level about P wave duration. Vitamin D, CRP and LDL level may inform about ventricular arrhythmia and atrial fibrillation risk, respectively, in hypertensive patients.