A practical guide to thiopurine prescribing and monitoring in IBD. Issue 1 (29th August 2016)

• Record Type: Journal Article
• Authors: Warner, Ben; Johnston, Emma; Arenas-Hernandez, Monica; Marinaki, Anthony; Irving, Peter; Sanderson, Jeremy
• Is Part Of: Frontline gastroenterology. Volume 9:Issue 1(2018)
• Page Start: 10
• Page End: 15
• Publication Date: 2016-08-29
• Subjects: AZATHIOPRINE -- 6-MERCAPTOPURINE -- INFLAMMATORY BOWEL DISEASE -- THIOPURINE METHYLTRANSFERASE -- ADVERSE DRUG REACTIONS; Gastroenterology -- Periodicals; 616.33005
• DOI: 10.1136/flgastro-2016-100738
• Languages: English
• ISSNs: 2041-4137

Abstract

Abstract : Thiopurines are often the mainstay of treatment for many patients with inflammatory bowel disease. As such, a general understanding of the evidence behind their use and of their metabolism is extremely useful in clinical practice. This review gives a practical overview of thiopurine metabolism, the importance of thiopurine S-methyltransferase testing prior to the start of therapy and the monitoring of thioguanine nucleotide levels while on treatment, guiding a personalised approach to optimising thiopurine therapy.