Specific Blood Cells Derived from Pluripotent Stem Cells: An Emerging Field with Great Potential in Clinical Cell Therapy. (15th August 2021)

• Record Type: Journal Article
• Authors: Luo, Qian; Li, Honghu; Shan, Wei; Wei, Cong; Long, Yan; Cai, Shuyang; Zeng, Xiangjun; Li, Xue; Xu, Yulin; Xu, Xiaoxiao; Luo, Yi; Qian, Pengxu; Huang, He
• Other Names: Zimmerlin Ludovic Academic Editor.
• Is Part Of: Stem cells international. Volume 2021(2021)
• Publication Date: 2021-08-15
• Subjects: Stem Cells -- Periodicals; Stem Cells -- Therapeutic use -- Periodicals; Stem Cells -- Transplantation -- Periodicals; 616.0277405
• DOI: 10.1155/2021/9919422
• Languages: English
• ISSNs: 1687-966X

Abstract

Abstract : Widely known for self-renewal and multilineage differentiation, stem cells can be differentiated into all specialized tissues and cells in the body. In the past few years, a number of researchers have focused on deriving hematopoietic stem cells (HSCs) from pluripotent stem cells (PSCs) as alternative sources for clinic. Existing findings demonstrated that it is feasible to obtain HSCs and certain mature blood lineages from PSCs, except for several issues to be addressed. This short review outlines the technologies used for hematopoietic differentiation in recent years. In addition, the therapeutic value of PSCs as a potential source of various blood cells is also discussed as well as its challenges and directions in future clinical applications.