13. GARLIC EFFECT ON REDUCE BLOOD PRESSURE AND CHOLESTEROL IN PATIENTS WITH AND WITHOUT HYPERTENSION: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS. (May 2021)

• Record Type: Journal Article
• Authors: Mulawarman, Rido; Trifitriana, Monica; Felani, Muhammad Rizky; Mulawarman, ; Tondas, Alexander Edo
• Is Part Of: Journal of hypertension. Volume 39(2021)e-Supplement 2
• Publication Date: 2021-05
• Subjects: garlic -- blood pressure -- hypertension -- meta-analysis; Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/01.hjh.0000752400.24367.fa
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Background: Garlic has been linked to improved cardiovascular health. Garlic has been suggested to lower blood pressure, plasma lipids as well as an antiplatelet effect and other cardiovascular markers. Objective: We aim to assess the latest evidence on the effect of garlic on blood pressure and cholesterol in patients with and without hypertension through systematic review and meta-analysis. Method: We performed a comprehensive search on topics that assesses garlic outcomes in patients with and without hypertension from inception up until December 2020. Results: There were a total of 503 patients from 12 controlled trial studies. Pooled systolic blood pressure was lower in garlic group (mean difference -3.62 [-5.43, -1.80], p = <0.000001; I 2 : 85%, p < 0.0001). Meta-analysis showed that diastolic blood pressure was lower in garlic group (mean difference -1.40 [-2.72, -0.08], p = <0.00001; I 2 : 86%, p = 0.04) on follow-up. Total cholesterol was also lower in garlic group (mean difference -17.17 [-28.57, -5.78], p < 0.00001; I 2 : 86%, p = 0.003). Level of heart rate was similar in garlic and placebo group. Conclusion: This meta-analysis suggests that garlic is associated with reducing blood pressure and cholesterol in patients with and without hypertension. Future long-term trials are needed to elucidate the impact of garlic on cardiovascular morbidity and mortality.