Age-Specific Seroprevalence of Human Papillomavirus 16, 18, 31, and 58 in Women of a Rural Town of Colombia. Issue 2 (1st February 2012)

• Record Type: Journal Article
• Authors: Bedoya, Astrid M.; Gaviria, Angela M.; Baena, Armando; Borrero, Mauricio; Duarte, Diego F.; Combita, Alba L.; Castaño, Jorge; Grisales, Hugo; Sánchez, Gloria I.
• Is Part Of: International journal of gynecological cancer. Volume 22:Issue 2(2012)
• Page Start: 303
• Page End: 310
• Publication Date: 2012-02-01
• Subjects: Human papillomavirus antibodies -- Human papillomavirus vaccine -- Colombia -- Cervical cancer -- Women's health; Generative organs, Female -- Cancer -- Periodicals; 616.99465
• DOI: 10.1097/IGC.0b013e31823c2469
• Languages: English
• ISSNs: 1048-891X

Abstract

Abstract : Objective: The study's objective was to estimate human papillomavirus (HPV) genotype–specific seroprevalence to determine population HPV exposure and inform vaccine policy. Methods: This study is a cross-sectional prevalence survey of 878 women of Pueblorrico, a rural town of Colombia. A standardized questionnaire was used to obtain information on demographic characteristics, sexual and reproductive history, and smoking habits. Seropositivity to HPV-16, -18, -31, and -58 was determined by virus-like particles in an enzyme-linked immunosorbent assay. Results: Overall seropositivity to any HPV genotype was 27.9%. The combined seroprevalence of women 15 to 19 and 20 to 24 years old was 35.4% (95% confidence interval [CI], 25.9–46.2) and 36.0% (95% CI, 27.7–45.3), respectively. Seroprevalence for HPV-16 was 17% (95% CI, 14.6–19.6); for HPV-18, 9.8% (95% CI, 8.0–11.9); for HPV-31, 11.4% (95% CI, 9.5–13.7); and for HPV 58, 12.5% (95% CI, 10.5–14.9). Higher HPV seropositivity was associated with the lifetime number of occasional sexual partners (odds ratio, 3.05; 95% CI, 1.26–7.37) and having more than 2 regular sexual partners (odds ratio, 3.00; 95% CI, 1.21–7.45) in women younger than 44 and older than 45 years old, respectively. Use of oral contraceptives and tobacco/cigarettes was significantly associated with reduced HPV seropositivity in women older than 45 but not in women younger than 44 years old. Conclusions: Human papillomavirus seropositivity is associated with measures of sexual behavior, particularly a greater lifetime number of sexual partners. Hormonal and tobacco/cigarette use may be factors influencing the HPV seropositivity in women older than 45 years old.