Incidence and survival of retinoblastoma in Taiwan: a nationwide population-based study 1998–2011. Issue 6 (14th September 2015)

• Record Type: Journal Article
• Authors: Li, Su-Yin; Chen, Solomon Chih-Cheng; Tsai, Ching-Fang; Sheu, Shew-Meei; Yeh, Jun-Jun; Tsai, Chong-Bin
• Is Part Of: British journal of ophthalmology. Volume 100:Issue 6(2016)
• Page Start: 839
• Page End: 842
• Publication Date: 2015-09-14
• Subjects: Epidemiology -- Neoplasia -- Child health (paediatrics); Ophthalmology -- Periodicals; 617.7
• DOI: 10.1136/bjophthalmol-2015-307211
• Languages: English
• ISSNs: 0007-1161

Abstract

Abstract : Objective: To study the epidemiology of retinoblastoma in Taiwan from 1998 to 2011. Design: This was a retrospective population-based cohort study using the Taiwan National Health Insurance Research Database. Results: The present study included 154 patients (92 males, 62 females) with retinoblastoma and the documented overall retinoblastoma incidence was 1 in 17 373 live births without a notable trend over the study period. The incidence per million live births examined by gender was 65.8 for males and 48.5 for females. The age-specific sex ratio increased from 1.4 at age younger than 1 year to 3.0 above age 4 years. Enucleation was performed in 109 (70.8%) children with retinoblastoma, and it was more prevalent in males than in females (77.2% vs 61.3%, p=0.0335). Multivariate Cox regression analyses with adjustment for diagnostic age, sex, and birth year elucidated that enucleation was a significant factor associated with survival (OR 0.27, 95% CI 0.10 to 0.61). Conclusions: The incidence of retinoblastoma in Taiwan exhibited no marked trend over time. There were more cases of males than females and the male-to-female rate ratio increased with age. Survival outcome was significantly associated with the intervention of enucleation.