A cross-sectional study of lung function and respiratory symptoms among chemical workers producing diacetyl for food flavourings. Issue 2 (19th September 2008)

• Record Type: Journal Article
• Authors: van Rooy, F G B G J; Smit, L A M; Houba, R; Zaat, V A C; Rooyackers, J M; Heederik, D J J
• Is Part Of: Occupational and environmental medicine. Volume 66:Issue 2(2009)
• Page Start: 105
• Page End: 110
• Publication Date: 2008-09-19
• Subjects: Medicine, Industrial -- Periodicals; Environmental health -- Periodicals; 616.980305
• DOI: 10.1136/oem.2008.039560
• Languages: English
• ISSNs: 1351-0711

Abstract

Abstract : Objectives: Four diacetyl workers were found to have bronchiolitis obliterans syndrome. Exposures, respiratory symptoms, lung function and exposure–response relationships were investigated. Methods: 175 workers from a plant producing diacetyl between 1960 and 2003 were investigated. Exposure data were used to model diacetyl exposure. Lung function and questionnaire data on respiratory symptoms were compared to a general population sample and respiratory symptoms to an internal reference group. Results: Workers were potentially exposed to acetoin, diacetyl, acetaldehyde and acetic acid. Historic diacetyl exposure ranged from 1.8 to 351 mg/m 3, and from 3 to 396 mg/m 3 for specific tasks. Diacetyl workers reported significantly more respiratory symptoms compared to the general population sample (continuous trouble with breathing (prevalence ratio (PR) = 2.6; 95% CI 1.3 to 5.1), daily cough (PR = 1.5; 95% CI 1.1 to 2.1), asthma attack (ever) (PR = 2.0; 95% CI 1.2 to 3.4), doctor diagnosed asthma (PR = 2.2; 95% CI 1.3 to 3.8) and asthma attack in the last year (PR = 4.7; 95% CI 1.9 to 11.4)) and to a minimally exposed internal reference group (ever trouble with breathing (PR = 2.8; 95% CI 1.1 to 7.0) and work-related shortness of breath in the last year (PR = 7.5; 95% CI 1.1 to 52.9)). Lung function did not differ between groups. A positive relationship between exposure and FEV1 was found. Conclusion: The excess of respiratory symptoms in this retrospective cohort suggests that diacetyl production poses an occupational hazard. Limited historical exposure data did not support a quantitative individual diacetyl exposure–response relationship, but our findings suggest that preventive measures are prudent.