Adverse effects of low occupational cadmium exposure on renal and oxidative stress biomarkers in solderers. Issue 2 (26th October 2012)

• Record Type: Journal Article
• Authors: Hambach, Ramona; Lison, Dominique; D'Haese, Patrick; Weyler, Joost; François, Guido; De Schryver, Antoon; Manuel-Y-Keenoy, Begoña; Van Soom, Ulrik; Caeyers, Tine; van Sprundel, Marc
• Is Part Of: Occupational and environmental medicine. Volume 70:Issue 2(2013)
• Page Start: 108
• Page End: 113
• Publication Date: 2012-10-26
• Subjects: Medicine, Industrial -- Periodicals; Environmental health -- Periodicals; 616.980305
• DOI: 10.1136/oemed-2012-100887
• Languages: English
• ISSNs: 1351-0711

Abstract

Abstract : Objectives: Recent studies suggest adverse health effects after low exposure to cadmium (Cd). Brazing with Cd-containing solder exposes workers to Cd. The purpose of this study was to assess: (1) indicators of Cd exposure in blood (Cd-B)/ urine (Cd-U); (2) the association between Cd-B, Cd-U and renal and oxidative stress biomarkers. Methods: In this cross-sectional study Cd-B, Cd-U, renal (ie, N-acetyl-β-D-glucosaminidase/urinary intestinal alkaline phosphatase (IAP)/microalbumin/beta-2-microglobulin/retinol binding protein and oxidative stress markers (ie, derivatives of reactive oxygen metabolites/glutathione peroxidase/superoxide dismutase (SOD)/ advanced oxidation protein products/8-hydroxy-2′-deoxyguanosin/8-isoprostanes) were determined in 36 solderers. Results: Multiple linear regression analysis adjusting for age and pack-years of smoking show that IAP is statistically significantly associated with Cd-B (B=0.24; SE=0.11) and Cd-U (B=0.15; SE=0.07). Also SOD is statistically significantly associated with Cd-B (B=62.96; SE=29.62). The association between SOD and Cd-U is of borderline statistical significance (B=37.69; SE=19.59). Conclusions: While there is still some debate as whether the Cd-induced tubular effects are reversible or not, IAP and SOD appear as sensitive and potentially useful early biomarkers for the health surveillance of workers exposed to low levels of Cd.