Lung cancer risk among men by occupation and industry in SYNERGY – pooled analysis of case-control studies on the joint effects of occupational carcinogens in the development of lung cancer. (19th October 2011)

• Record Type: Journal Article
• Authors: Mirabelli, Dario; Merletti, Franco; Richiardi, Lorenzo; Corbin, Marine; Franch, Iván Marín; Olsson, Ann; Gustavsson, Per; Kromhout, Hans; Peters, Susan; Vermeulen, Roel; Brüske, Irene; Pesch, Beate; Brüning, Thomas; Gross, Isabelle; Siemiatycki, Jack; Pintos, Javier; Wichmann, Heinz-Erich; Consonni, Dario; Plato, Nils; Ahrens, Wolfgang; Pohlabeln, Hermann; Lissowska, Jolanta; Szeszenia-Dabrowska, Neonila; Cassidy, Adrian; Zaridze, David; Stücker, Isabelle; Benhamou, Simone; Bencko, Vladimir; Foretova, Lenka; Janout, Vladimir; Rudnai, Peter; Fabianova, Eleonora; Mates, Dana; Bueno-de-Mesquita, Bas; Boffetta, Paolo; Straif, Kurt;
• Is Part Of: Occupational and environmental medicine. Volume 68(2011)Supplement 1
• Page Start: A46
• Page End: A46
• Publication Date: 2011-10-19
• Subjects: Medicine, Industrial -- Periodicals; Environmental health -- Periodicals; 616.980305
• DOI: 10.1136/oemed-2011-100382.149
• Languages: English
• ISSNs: 1351-0711

Abstract

Abstract : Objectives: Exploratory analyses by occupation or industry are commonly conducted in case-control studies. However, cancer risks limited to certain jobs within an industry, or to a job within a given industry, become undetectable in the overall industry or job odds-ratio. Using the SYNERGY dataset we conducted an analysis based on occupations and industries combined. Methods: Data included 10 917 male cases and 13 154 male controls. Industries and jobs were coded according to ISIC Revision 2 and ISCO 1968, respectively. Odds-ratios were computed for ISCO-ISIC combinations with ≥10 study subjects, adjusting for study, age, and smoking. To allow for multiple comparisons we applied a semi-Bayes approach, shrinking towards a group mean the estimate for each ISCO-ISIC combination, previously classified as: occupation known or suspected to entail lung cancer risk, other manual workers, other non-manual workers. Results: Out of 1187 evaluated ISCO-ISIC combinations, 50 had an increased odds-ratio (p<0.05). For 26 combinations the risk remained elevated after semi-Bayes shrinkage. As an example, painters in car repair, but not in other industries like car building, had an increased risk (odds-ratio after shrinkage: 1.79, 95% CI 1.04 to 3.07). Likewise, only 8 jobs had increased risk among 63 analysed within the construction industry: miners (2.05, 1.18 to 3.55), bricklayers (1.57, 1.37 to 1.80), welders (1.57, 1.08 to 2.28), earth-moving operators (1.36, 1.05 to 1.76), carpenters (1.30, 1.08 to 1.57), other workers (1.24, 1.06 to 1.44), plumbers (1.23, 1.02 to 1.49) and labourers (1.20, 1.05 to 1.36). Conclusions: The use of ISCO-SIC combinations and a semi-Bayes approach identified specific jobs within specific industries with an increased lung cancer risk.