0427 A cohort study of workers exposed to PFOA. (23rd June 2014)
- Record Type:
- Journal Article
- Title:
- 0427 A cohort study of workers exposed to PFOA. (23rd June 2014)
- Main Title:
- 0427 A cohort study of workers exposed to PFOA
- Authors:
- Steenland, Kyle
Zhao, Liping
Winquist, Andrea - Abstract:
- Abstract : Objectives: PFOA has been linked to several diseases, but findings are inconclusive, and there have been no incidence studies in worker populations. Method: We interviewed 3700 workers or their next-of-kin in 2009–2011 for medical history, and sought medical records to validate self-reported disease. A job-exposure matrix based on over 2000 PFOA serum measurements was used to estimate serum levels over time for each worker, while a separate estimation was made for non-occupational exposure due to drinking PFOA-contaminated water. Cumulative dose in the serum (ng/ml-years) was the metric of interest. We studied 18 disease outcomes with 15 to 1430 cases; analyses were limited to confirmed cases. Results: The median year of birth was 1951; 5% had died. The median measured serum level was 113 ng/ml in 2005 (n = 1900), compared to 4 ng/ml in the US population. Among 18 outcomes studied, only ulcerative colitis (10 year lag) showed a significant trend with increasing exposure (p = 0.05) (RRs by quartile 1.00, 3.00, 3.26, 6.57, p value trend 0.05), similar to earlier findings in a community cohort study in the same area. Positive but non-significant trends were also observed for prostate cancer and non-hepatitis liver disease, and female hypothyroidism, which have been implicated in other studies, No marked trends were seen for high cholesterol, which had been seen in the community study. Conclusions: Ulcerative colitis was linked to PFOA exposure among workers. AnalysesAbstract : Objectives: PFOA has been linked to several diseases, but findings are inconclusive, and there have been no incidence studies in worker populations. Method: We interviewed 3700 workers or their next-of-kin in 2009–2011 for medical history, and sought medical records to validate self-reported disease. A job-exposure matrix based on over 2000 PFOA serum measurements was used to estimate serum levels over time for each worker, while a separate estimation was made for non-occupational exposure due to drinking PFOA-contaminated water. Cumulative dose in the serum (ng/ml-years) was the metric of interest. We studied 18 disease outcomes with 15 to 1430 cases; analyses were limited to confirmed cases. Results: The median year of birth was 1951; 5% had died. The median measured serum level was 113 ng/ml in 2005 (n = 1900), compared to 4 ng/ml in the US population. Among 18 outcomes studied, only ulcerative colitis (10 year lag) showed a significant trend with increasing exposure (p = 0.05) (RRs by quartile 1.00, 3.00, 3.26, 6.57, p value trend 0.05), similar to earlier findings in a community cohort study in the same area. Positive but non-significant trends were also observed for prostate cancer and non-hepatitis liver disease, and female hypothyroidism, which have been implicated in other studies, No marked trends were seen for high cholesterol, which had been seen in the community study. Conclusions: Ulcerative colitis was linked to PFOA exposure among workers. Analyses of other diseases did not show marked trends. Data were limited by small numbers, a largely survivor cohort, and few low exposed referents. … (more)
- Is Part Of:
- Occupational and environmental medicine. Volume 71(2014)Supplement 1
- Journal:
- Occupational and environmental medicine
- Issue:
- Volume 71(2014)Supplement 1
- Issue Display:
- Volume 71, Issue 1 (2014)
- Year:
- 2014
- Volume:
- 71
- Issue:
- 1
- Issue Sort Value:
- 2014-0071-0001-0000
- Page Start:
- A55
- Page End:
- A55
- Publication Date:
- 2014-06-23
- Subjects:
- Medicine, Industrial -- Periodicals
Environmental health -- Periodicals
616.980305 - Journal URLs:
- http://oem.bmj.com/ ↗
http://www.jstor.org/journals/13510711.html ↗
http://www.pubmedcentral.nih.gov/tocrender.fcgi?journal=172&action=archive ↗
http://www.bmj.com/archive ↗ - DOI:
- 10.1136/oemed-2014-102362.170 ↗
- Languages:
- English
- ISSNs:
- 1351-0711
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - BLDSS-3PM
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- 19229.xml