Facile Engineering of Anti‐Inflammatory Nanotherapies by Host‐Guest Self‐Assembly. Issue 28 (27th July 2020)

• Record Type: Journal Article
• Authors: Yang, Guoyu; Wu, Peng; Yu, Cong; Zhang, Jianxiang; Song, Jinlin
• Is Part Of: ChemistrySelect. Volume 5:Issue 28(2020)
• Page Start: 8707
• Page End: 8716
• Publication Date: 2020-07-27
• Subjects: anti-inflammatory drugs -- drug delivery -- host-guest systems -- nanotherapy -- self-assembly; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.202001590
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: Anti‐inflammatory drugs have been broadly used for the treatment of different diseases, but many of them have low water‐solubility, thereby leading to poor bioavailability and limited clinical benefits. Herein we report host‐guest assembly of nanotherapies based on different hydrophobic anti‐inflammatory drugs, in which β‐cyclodextrin (β‐CD)‐conjugated polyethyleneimine (PEICDs) were used as host polymers. The spontaneous assembly and nanotherapy formation by PEICDs was first demonstrated using a nonsteroidal anti‐inflammatory drug indomethacin, showing high loading efficiencies and loading contents. Besides inclusion interactions, hydrogen‐bonding and electrostatic forces are responsible for effective host‐guest assembly. Moreover, this facile and robust approach can be generalized to other hydrophobic drugs. Due to the amorphous distribution of loaded drug molecules in nanotherapies, they can be rapidly and completely released, with the release rate relevant to the binding free energy between drug and β‐CD. Accordingly, this host‐guest assembly strategy is promising for developing effective anti‐inflammatory nanotherapies. Abstract : A host‐guest assembly strategy is developed for engineering nanotherapies based on different hydrophobic anti‐inflammatory drugs, in which β‐cyclodextrin‐containing hydrophilic polymers serve as host materials. Thus assembled nanotherapies show high loading efficiencies and loading contents for anti‐inflammatory agents with diverse structures. The packaged drug molecules in nanotherapies can be rapidly and completely released. This approach is promising for creating effective anti‐inflammatory nanotherapies.