Blennolide derivatives from the soil-derived fungus Trichoderma asperellum PSU-PSF14. Issue 39 (27th September 2018)

• Record Type: Journal Article
• Authors: Maha, Athip; Phainuphong, Patima; Rukachaisirikul, Vatcharin; Saithong, Saowanit; Phongpaichit, Souwalak; Hadsadee, Sarinya; Jungsuttiwong, Siriporn; Preedanon, Sita; Sakayaroj, Jariya
• Is Part Of: Tetrahedron. Volume 74:Issue 39(2018)
• Page Start: 5659
• Page End: 5664
• Publication Date: 2018-09-27
• Subjects: Trichoderma asperellum -- Soil-derived fungus -- Blennolide derivatives -- Antifungal activity -- Cytotoxic activity; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tet.2018.07.041
• Languages: English
• ISSNs: 0040-4020

Abstract

Abstract: Three new blennolide derivatives, blennolides L-N (1 –3 ), together with five known metabolites were isolated from the soil-derived fungus Trichoderma asperellum PSU-PSF14. Their structures were determined by analysis of spectroscopic data. Their relative configurations were determined by analysis of NOEDIFF data and confirmed by X-ray crystallography for compound 1 whereas the absolute configurations were established by means of experimental and calculated TDDFT ECD data. Compound 1 displayed antifungal activity against Cryptococcus neoformans ATCC90112 and ATCC90113 flucytosine-resistant with the MIC values of 128 and 64 μg/mL, respectively, and was inactive against noncancerous Vero cell lines. Graphical abstract: Image 1