Environmental exposure to metals and the risk of hypertension: A cross-sectional study in China. (February 2018)

• Record Type: Journal Article
• Authors: Wu, Weixiang; Jiang, Shunli; Zhao, Qiang; Zhang, Ke; Wei, Xiaoyun; Zhou, Tong; Liu, Dayang; Zhou, Hao; Zeng, Qiang; Cheng, Liming; Miao, Xiaoping; Lu, Qing
• Is Part Of: Environmental pollution. Volume 233(2018)
• Page Start: 670
• Page End: 678
• Publication Date: 2018-02
• Subjects: Urinary metal -- Environmental exposure -- Epidemiology -- Hypertension -- Blood pressure; Pollution -- Periodicals; Pollution -- Environmental aspects -- Periodicals; Environmental Pollution -- Periodicals; Pollution -- Périodiques; Pollution -- Aspect de l'environnement -- Périodiques; Pollution -- Effets physiologiques -- Périodiques; Pollution; Pollution -- Environmental aspects; Periodicals; Electronic journals; 363.73
• DOI: 10.1016/j.envpol.2017.10.111
• Languages: English
• ISSNs: 0269-7491

Abstract

Abstract: Metal pollution is a severe environmental issue in China, which has been recently linked with the risk of hypertension. However, relevant epidemiological studies are limited. The present exploratory study was conducted to assess the associations of environmental exposure to metals with the odds of hypertension as well as blood pressure (BP) levels using urine samples in a Chinese general population. From May 2016 to April 2017, a total of 823 eligible participants were consecutively enrolled in our study in Wuhan, China. Hypertension was defined as systolic BP (SBP) of ≥140 mmHg or diastolic BP (DBP) of ≥90 mmHg, a self-reported physician diagnosis, or current use of antihypertensive medication. We used urine samples as biomarkers to reflect the levels of environmental exposure to 20 metals. Multivariable regression models were applied to assess the potential association. Multi-metal models were conducted to investigate the impacts of co-exposure to various metals. Based on the results from various models, positive trends for increased odds of hypertension with increasing quartiles of vanadium (V), iron (Fe), zinc (Zn) and selenium (Se) were suggested. Compared with those in the lowest quartiles, participants in the highest quartiles of V, Fe, Zn and Se had a 4.4-fold, 4.9-fold, 4.2-fold and 2.5-fold increased odds of having hypertension, respectively. High urinary Hg level was found to increase the levels of DBP. Individuals in the highest group of Hg were found to have a 4.3 mmHg higher level of DBP. Our findings suggest that environmental exposure to V, Fe, Zn, Se and Hg might increase the risk of hypertension or elevate the levels of BP. These findings warrant further prospective studies in a larger population. Graphical abstract: Image 1 Highlights: First study on the associations of urinary metal profiles with hypertension in China. Multi-metal models that considered the co-exposure effects of various metals were applied. Environmental exposure to V, Fe, Zn and Se might contribute to the prevalence of hypertension. High urinary Hg levels were found to increase the levels of DBP. Abstract : Our findings suggest that environmental exposure to V, Fe, Zn, Se and Hg might increase the risk of hypertension.