A pilot study of biomarkers of oxidative stress in serum and schizophrenia. (February 2020) - Ma, Jiahui
Highlights: Oxidative stress and inflammation may contribute to the development of schizophrenia. We recruited 44 patients with schizophrenia and 45 healthy controls. Four typical oxidative stress and inflammatory biomarkers in their fasting blood samples were measured. This study combines a questionnaire survey and serum analysis of four oxidant biomarkers based on the same population to screen for risk factors for schizophrenia. Serum concentrations of MCP-1 and IL-8 were positively correlated with schizophrenia risk. Abstract: Increasing evidence indicates that oxidative damage and inflammation is present in patients with schizophrenia. In this study, we investigated the association between the serum concentrations of four typical oxidative stress and inflammatory biomarkers (monocyte chemotactic protein-1, heme oxygenase-1, interleukin-8, and 8-Hydroxydeoxyguanine) and schizophrenia using a case-control study design. In total, 44 patients with schizophrenia and 45 normal controls from Shandong Province, China were recruited. Fasting blood samples were collected from all participants and the serum concentration of the four biomarkers were analyzed by Enzyme-linked immunosorbent assay. The concentrations of monocyte chemotactic protein-1 and interleukin-8 were significantly higher in the patients than in the controls, while there was no significant difference in the serum concentrations of heme oxygenase-1 and 8-Hydroxydeoxyguanine. Moreover, the serum concentrations of monocyte chemotactic protein-1 and interleukin-8 in patients were positively correlated with severity of clinical symptoms. Dose–response relationships between serum biomarker concentrations and schizophrenia were observed. This study suggests that levels of monocyte chemotactic protein-1 and interleukin-8 are increased in patients with schizophrenia and correlated with positive symptom severity.