Synthesis and 1H, 13C and 15N NMR characterisation of substituted Pyrazolo[4, 3-c]quinolines and related compounds. Issue 22 (31st May 2018)

• Record Type: Journal Article
• Authors: Black, Shannon L.; O'Connor, Patrick D.; Boyd, Maruta; Blaser, Adrian; Kendall, Jackie D.
• Is Part Of: Tetrahedron. Volume 74:Issue 22(2018)
• Page Start: 2797
• Page End: 2806
• Publication Date: 2018-05-31
• Subjects: NMR -- 1H NMR -- 13C NMR -- 15N NMR -- 1H-13C HMBC -- 1H-15N HMBC -- Pyrazolo[4, 3-c]quinolines; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tet.2018.04.061
• Languages: English
• ISSNs: 0040-4020

Abstract

Abstract: A wide range of novel and known alkyl substituted pyrazolo[4, 3- c ]quinolines and related compounds were synthesized. Some of these compounds can undergo tautomerism and differences have been noted in the structural assignments already published. For each of these compounds, a complete assignment was made using 1 H, 13 C and 15 N one- and two-dimensional NMR measurements, including NOESY, COSY, 1 H- 13 C HSQC and 1 H- 13 C HMBC. 1 H- 15 N HMBC NMR has proved crucial in determining the relevant tautomeric and protonated state of the compounds. Graphical abstract: Image 1