Fast near infrared light response hydrogel as medical dressing for wound healing. Issue 43 (3rd May 2020)

• Record Type: Journal Article
• Authors: Yang, Kai; Yin, Xinyu; Yan, Yuanyang; Luo, Guanzhou; Xu, Mengyi; Pi, Pihui; Xu, Shouping; Wen, Xiufang
• Is Part Of: Journal of applied polymer science. Volume 137:Issue 43(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-05-03
• Subjects: gels -- polysaccharides -- radical polymerization -- structure–property relationships; Polymers -- Periodicals; Polymerization -- Periodicals; 668.9
• DOI: 10.1002/app.49309
• Languages: English
• ISSNs: 0021-8995

Abstract

Abstract: Fast‐response smart hydrogels with combination of appropriate mechanical strength, self‐healing and tissue adhesiveness ability, and controllable drug release performance are highly desired as wound dressing practice. Herein, a novel dual‐crosslinking hydrogel with gold nanorods (AuNRs) well dispersed in its polymer network, D‐hydrogel@AuNR, was constructed via ultraviolet light initiated radical copolymerization of acrylamide (AM), isopropylacrylamide (NIPAAM), and dopamine methacrylamide (DMA) in a complex solution of AuNRs and cysteamine‐grafted oxidized sodium alginate (OSA‐SH). The produced D‐hydrogel@AuNR exhibits fast response to the near infrared light (NIR, 808 nm) exposure and a cumulative release level of encapsulated gentamicin sulfate (GS) up to 75% within 60 s laser irradiation. The dual‐crosslinking network that the first MBA crosslinked P(AM‐co‐NIPAAM‐co‐DMA) network and the second imine bonded network makes the tensile stress and tensile strain of D‐hydrogel@AuNR could reach up to 397.0 k Pa and 240%, respectively. Moreover, the received D‐hydrogel@AuNR also exhibits remarkable self‐healing ability and excellent cell affinity and tissue adhesiveness. These desirable properties of D‐hydrogel@AuNR together make it an appropriate candidate for practical wound dressing under different biomedical conditions. Abstract :