Direct Electrochemistry and Sensitive Detection of Guanosine on Nanopolymeric Surfaces Bearing Boronic Acid Groups. Issue 29 (4th August 2020)

• Record Type: Journal Article
• Authors: Kuralay, Filiz; Gürsoy, Taner
• Is Part Of: ChemistrySelect. Volume 5:Issue 29(2020)
• Page Start: 9134
• Page End: 9142
• Publication Date: 2020-08-04
• Subjects: Electroactive Surfaces -- Guanosine -- Nanostructures -- Nucleosides -- Poly(3-aminophenylboronic acid); Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.202001812
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: This paper describes the use of novel boronic acid containing polymeric surfaces for following improved direct electrochemistry and highly sensitive and selective electrochemical detection of guanosine. Effective and robost boronic acid containing electroactive polymeric layers based on poly(3‐aminophenylboronic acid) (PAPBA) in the existence of a convenient nanomaterial (multi‐walled carbon nanotubes, MWCNTs) were fabricated onto graphite surfaces with a simple and reproducible single‐step electro‐fabrication method for the first time. So‐formed electrodes were then utilized for direct electrochemistry of guanosine and determination of guanosine. The electrode presented a linearity to guanosine from 1 μM to 120 μM and the detection limit was calculated as 0.14 μM (n=3). It was feasible to differentiate guanine and guanosine with a good peak separation value of 0.31 V. Furthermore, analytical performance of this novel electrode was compared with the performances of graphene added polymeric layer modified graphite electrode and unmodified graphite electrode. Abstract : Polymer surfaces containing boronic acid groups and carbon nanotubes were constructed on disposable electrodes. So‐formed surfaces were used for improved electrochemistry and sensitive detection of guanosine. These robost surfaces exhibited high accuracy and precision in untreated urine samples. Furthermore, polymeric surfaces having boronic acid groups and graphene were fabricated. Analytical performances of these novel surfaces were discussed and compared.