Evidence for an environmental effect in the aetiology of insulin dependent diabetes in a transmigratory population. Issue 6833 (18th April 1992)

• Record Type: Journal Article
• Authors: Bodansky, H. J.; Staines, A.; Stephenson, C.; Haigh, D.; Cartwright, R.
• Is Part Of: BMJ. Volume 304:Issue 6833(1992)
• Page Start: 1020
• Page End: 1022
• Publication Date: 1992-04-18
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Medicine; Periodicals; 610
• DOI: 10.1136/bmj.304.6833.1020
• Languages: English
• ISSNs: 0007-1447

Abstract

Abstract : OBJECTIVE--To examine whether children of families moving from an area of low incidence of childhood diabetes to one which is higher show a corresponding rise in disease incidence. DESIGN--Disease incidence study over 12 years. SETTING--Bradford District Metropolitan Council area. SUBJECTS--All subjects aged 0-16 years resident within the study area. MAIN OUTCOME MEASURES--The incidences of childhood diabetes in Asian and non-Asian families. RESULTS--The incidence of diabetes in Asian children increased from 3.1/100, 000 per year in 1978-81 to 11.7/100, 000 per year in 1988-90 (chi 2 for trend = 4.95, df = 1, p = 0.026) whereas that for other children remained constant at 10.5/100, 000 per year. Over the entire study period rates were lower in Asian females (4.9/100, 000 per year) than in Asian males (8.8/100, 000 per year) whereas the reverse was true for other children (males 9.2/100, 000 per year; females 12.0/100, 000 per year) (test for common odds ratio: chi 2 = 3.81, df = 1, p = 0.052). CONCLUSIONS--Offspring of this transmigratory population had a rising incidence of childhood diabetes which was approaching that of the indigenous population. The data provide strong evidence for an environmental effect in the aetiology of insulin dependent diabetes.