Exercise in multiple sclerosis and its models: Focus on the central nervous system outcomes. Issue 3 (4th September 2019)

• Record Type: Journal Article
• Authors: Guo, Ling Yi; Lozinski, Brian; Yong, Voon Wee
• Other Names: Berglund Ken guestEditor.; Gross Robert E. guestEditor.
• Is Part Of: Journal of neuroscience research. Volume 98:Issue 3(2020)
• Page Start: 509
• Page End: 523
• Publication Date: 2019-09-04
• Subjects: neuroinflammation -- neuroprotection -- oligodendrocytes -- physical activity -- remyelination; Neurobiology -- Periodicals; 612
• DOI: 10.1002/jnr.24524
• Languages: English
• ISSNs: 0360-4012

Abstract

Abstract: Multiple sclerosis (MS) is a central nervous system (CNS) disorder characterized by inflammation, demyelination, and neurodegeneration. Emerging research suggests that exercise has therapeutic benefits for MS patients but the clinical data have focused primarily on non‐CNS outcomes. In this review, we discuss evidence in preclinical MS models that exercise influences oligodendrocyte proliferation and repopulation, remyelination, neuroinflammation, neuroprotection, axonal regeneration, and astrogliosis. Evidence for the therapeutic effects of exercise in MS is further supplemented by data from other CNS diseases, including Alzheimer's disease, Parkinson's disease, and spinal cord injury. These results motivate studies into the benefits that exercise confers within the CNS in MS.