Bile salt transport in the Dubin-Johnson syndrome. Issue 10 (October 1980)

• Record Type: Journal Article
• Authors: Douglas, J G; Beckett, G J; Percy-Robb, I W; Finlayson, N D
• Is Part Of: Gut. Volume 21:Issue 10(1980)
• Page Start: 890
• Page End: 893
• Publication Date: 1980-10
• Subjects: Gastroenterology -- Periodicals; 616.33
• DOI: 10.1136/gut.21.10.890
• Languages: English
• ISSNs: 0017-5749

Abstract

Abstract : Serum bile salt measurements and intravenous clearance of glycocholate were performed in a woman with Dubin-Johnson syndrome. Fasting conjugated cholate concentration was raised and prolonged intravenous clearance of sodium glycocholate revealed a secondary rise in conjugated cholate concentration after two hours. The intravenous clearance of bromsulphthalein also showed a secondary rise. These findings support the proposal that Dubin-Johnson syndrome is not homogeneous and that in some patients a abnormality of bile salt clearance coexists with an abnormality of bilirubin nd bromsulphthalein clearance.